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Stem cell research & therapy|Peer-Reviewed
Autologous bone marrow mesenchymal stem cell mitochondrial transplantation in recurrent assisted reproductive technology failure: a randomized controlled trial.
Xiaoping Liu, Dandan Wang, Lei Jia, Weixi Chen, Rui Huang, Cong Fang, Cijie Du, Liang Yang, Xingguo Liu, Xiaoyan Liang
Abstract
Mitochondrial dysfunction contributes to poor embryo quality and recurrent assisted reproductive technology (ART) failure. Mitochondrial transplantation (MIT), which involves supplementing oocytes with exogenous mitochondria, has been proposed as a novel strategy to improve ART outcomes. However, both its clinical efficacy and safety remain unclear.
Keywords
<Keyword MajorTopicYN="N">Autologous bone marrow mesenchymal stem cellsEmbryo qualityMitochondrial transplantationRecurrent ART failure