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Stem cell research & therapy|Peer-Reviewed
Intracerebroventricular human mesenchymal stem cells induce MMP9-driven transient inflammation in Alzheimer's disease.
Su Hyeon Myeong, Na Kyung Lee, Na-Hee Lee, Soo Jin Choi, Hyo Jin Son, Jong Wook Chang, Hee Jin Kim, Duk L Na
Abstract
Mesenchymal stem cells (MSCs) are often considered hypoimmunogenic. However, a transient fever observed after intracerebroventricular (ICV) administration in a clinical trial suggests an acute host response. This study examines the mechanisms underlying this reaction, with a focus on MSC migration and the role of matrix metalloproteinase-9 (MMP9).
Keywords
<Keyword MajorTopicYN="N">5xFADAlzheimer diseaseInflammationIntracerebroventricular injectionMatrix metalloproteinase-9 (MMP9)Mesenchymal stem cells