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Stem cell research & therapy|Peer-Reviewed
IFN-γ induces hematopoietic stem cell myelopoiesis through Meis1 in tumor.
Xue Han, Minyi Zhao, Kexin Wang, Weiwei Ma, Songqi Zhu, Ruiqing Zhou, Uet Yu, Bangxue Jiang, Xiaoqing Bai, Peng Lei, Shunqing Wang
Abstract
The role of inflammation-induced myeloid-biased hematopoiesis in driving resistance to immune checkpoint blockade (ICB) is recognized, yet the intricate mechanisms through which tumors orchestrate it are not fully defined.
Keywords
<Keyword MajorTopicYN="N">Hematopoietic stem cells (HSCs)Interferon (IFN)-γMeis homeobox 1 (Meis1)Myeloid-derived suppressor cells (MDSCs)Myelopoiesis