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Stem cell research & therapy|Peer-Reviewed
Functional development of photoreceptors in human retinal organoids.
Yue Zhang, Mingxia Du, Yi-Han Wang, Min Li, Kangxin Jin, Deng Pan, Xiao Zhang, Zi-Bing Jin
Abstract
Retinal organoids (ROs) derived from human pluripotent stem cells are crucial for modeling retinal development and disease. However, the functional electrophysiological maturation of photoreceptors within ROs remains poorly characterized. This study aimed to define the functional maturation timeline of photoreceptors in human embryonic stem cell (hESC)-derived ROs.
Keywords
<Keyword MajorTopicYN="N">Ion channelPhotoreceptorRetinal organoidsWhole-cell patch-clamphESC