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Stem cell research & therapy|Peer-Reviewed
Engineered cardiac patches from hiPSC-derived cardiomyocytes.
Jonas Jawad, Mohammad Z Khan, Tamer Jabsheh, Daryoush Javidi
Abstract
Heart failure remains a leading global cause of morbidity and mortality, with limited capacity for myocardial regeneration following infarction. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a promising therapeutic resource due to their scalability, differentiation potential, and immunologic adaptability. Engineered cardiac patches, three-dimensional constructs of hiPSC-CMs combined with supporting cells and scaffolds, offer a strategy to deliver organized myocardium directly to injured hearts, overcoming the limitations of cell injection therapies.
Keywords
<Keyword MajorTopicYN="N">Cardiac patchCardiomyocytesHeart failureHuman induced pluripotent stem cellsRegenerative medicineRemuscularizationTissue engineering