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Stem cell research & therapy|Peer-Reviewed
Comprehensive assessment of the genomic stability of human induced pluripotent stem cells for clinical applications.
Kehua Zhang, Tao Na, Chuncui Jia, Xianghe Yuan, Meichen Guo, Xu Yang, Min Li, Wenwen Jia, Zhihui Bai, Jizhen Lu, Zhongmin Liu, Shufang Meng
Abstract
Human induced pluripotent stem cells (hiPSCs) may acquire genomic alterations during reprogramming and culture, which poses significant risks for clinical applications. Current detection methods, such as karyotyping analysis, often fail to identify critical submicroscopic variations. This highlights an urgent need for comprehensive genomic surveillance strategies.
Keywords
<Keyword MajorTopicYN="N">Cell therapyGenomic alterationsHuman induced pluripotent stem cellsOptical genome mappingQuality control