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Blood|Peer-Reviewed
Time of infusion does not significantly impact outcomes following CAR T-cell therapy in large B-cell lymphoma
Mark R. Dowling, Edward R. Scheffer Cliff, Anthony Jeffrey, Catelyn Cashion, Stephen Boyle, Jian Li, Thomas Buss, Ross MacDonald, Anastasia Edelkina, Hamish W. Scott, Nicole L. O’Leary, Michelle W. Keir, Safia Belbachir, David A. Westerman, Constantine S. Tam, P. Joy Ho, Simon J. Harrison, Allison Barraclough, Shafqat Inam, Emily Blyth, Andrea S. Henden, Vinay Vanguru, Michael J. Dickinson
Abstract
Abstract In this retrospective analysis of 584 patients who received chimeric antigen receptor T-cell therapy for large B-cell lymphoma at 6 Australian centers, no association was found between time of infusion and outcome, accounting for confounders, suggesting minimal clinical impact of chronobiology in this setting.