Back to Feed
Stem cell research & therapy|Peer-Reviewed
SLIT3/ROBO1 axis contributes to angiogenic-osteogenic coupling in endothelial progenitor cells and peripheral blood mesenchymal stem cells.
Qiong Rong, Ling Ma, Mengting Wang, Qian Liu, Yali Zhang, Zhi Yuan, Xiaobing Tan
Abstract
Early vascularization is one of the limitations of periodontal tissue engineering (PTE) based on mesenchymal stem cells (MSCs). Directed differentiation of endothelial progenitor cells (EPCs) into endothelial cells facilitates the osteogenic effect of MSCs. Therefore, this study constructed EPCs/peripheral blood derived-MSCs (EPCs/PBMSCs) sheets and evaluated their repair value and potential molecular mechanisms in bone regeneration.
Keywords
<Keyword MajorTopicYN="N">AngiopoiesisEndothelial progenitor cellMesenchymal stem cellOsteogenic differentiationTissue engineering