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Stem cell research & therapy|Peer-Reviewed
Dual roles of GDNF in enteric glial cell plasticity: direct transdifferentiation via the CaMKII/NeuroD1 pathway and cooperative regulation in a neural stem cell-inducing medium.
Wanying Jia, Hanlei Yan, Jingjing Huang, Wei Liu, Zihao Fu, Donghao Tian, Wenyao Xu, Xinlin Chen, Ya Gao, Hui Yu
Abstract
Hirschsprung disease (HSCR) is a congenital condition featuring aganglionosis in the distal colon, causing functional obstruction. While EGF and bFGF are well-characterized neurogenic factors, the precise mechanistic role of GDNF in modulating enteric glial cell plasticity remains incompletely understood.
Keywords
<Keyword MajorTopicYN="N">Calcium signalingEnteric glial cellGDNFHirschsprung diseaseMetabolic reprogrammingNeural stem cell