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Stem cells (Dayton, Ohio)|Peer-Reviewed
LARP7 Enhances the Potential of Dental Pulp Stem Cells to Promote Peripheral Nerve Repair.
Zihan Yang, Guanlin Qu, Xiping Wang, Li Wang, Lu Chen, Guiqiang Fu, Wenze Chen, Zitong Yang, Wenjing Li, Yuqiong Zhou, Jiacheng Jin, Linxi Zhou, Duohong Zou
Abstract
Peripheral nerve injuries (PNIs) present a persistent clinical challenge because of the intrinsically limited regenerative capacity of peripheral nerves. While dental pulp stem cells (DPSCs) exhibit significant neuroregenerative potential, their therapeutic efficacy is constrained by hostile microenvironments and inherent functional heterogeneity. Genetic modification may offer a promising strategy to enhance their therapeutic capabilities.
Keywords
<Keyword MajorTopicYN="N">mesenchymal stem cellperipheral nerve injuriesregenerative medicinestem cell therapytissue regeneration