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Stem cell research & therapy|Peer-Reviewed
PW1+ cells give rise to cardiac adipocytes during development and myofibroblasts following injury.
Yuanxin Wei, Shan Kou, Lieyang Qin, Defang Deng, Wen Zhang, Jufeng Meng, Teng Feng, Chen Liu, Juan Tang, Hui Zhang
Abstract
Pw1, a maternally imprinted gene, is expressed in various stem cell populations, underscoring its crucial roles in tissue development, maintenance, and regeneration. While our recent work has revealed its regulatory function in cardiac fibrosis following ischemic injury, whether PW1+ cells exhibit stem cell properties in the heart remains unclear.
Keywords
<Keyword MajorTopicYN="N">AdipocyteMesenchymal cellMyocardial infarctionMyofibroblastPW1