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Stem cell research & therapy|Peer-Reviewed
Apelin-13 enhances BMSCs osteogenic differentiation and bone regeneration under hypoxia via upregulation of Ibsp.
Junming Tao, Xiaoning Qiu, Datian Fu, Si Wu, Zixing Wang, Chi Zhang, Mengru Hong, Shaochen Duan, Wei Jing
Abstract
Apelin-13 plays a critical role in promoting angiogenesis and regulating cellular metabolism. However, the short half-life of Apelin-13 in vivo limits its further applications. Stem cell transplantation has been widely applied in tissue regeneration, but the low survival rate of transplanted stem cells in vivo restricts its therapeutic efficacy. This study aims to combine Apelin-13 with stem cell transplantation to enhance the survival rate of transplanted stem cells and promote bone regeneration.
Keywords
<Keyword MajorTopicYN="N">Apelin-13Bone regenerationHypoxia