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Stem cell research & therapy|Peer-Reviewed
Dental pulp stem cell-derived exosomes attenuate psoriatic inflammation by restoring epithelial redox homeostasis via a miR-1246/miR-17-3p-GPX2-NF-κB axis.
Shuangshuang Wang, Dexuan Zhuang, Dongyu Hou, Tengfei Feng, Liliang Shen, Yuxin Shi, Qi Xu, Jing Guo, Xunwei Wu, Guohua Yuan
Abstract
Psoriasis is driven by sustained epidermal inflammation tightly coupled to dysregulated redox homeostasis. Although current systemic therapies are effective, their long-term use is limited by safety concerns. Dental pulp stem cell-derived exosomes (DPSC-Exo) have emerged as promising immunomodulatory, cell-free therapeutics, yet their role in regulating epithelial redox-inflammatory balance remains undefined.
Keywords
<Keyword MajorTopicYN="N">Dental pulp stem cell-derived exosomesGPX2 redox signalingPsoriasis