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Stem cell research & therapy|Peer-Reviewed
BMSC-derived EVs alleviate doxorubicin-induced cardiotoxicity via miR-210-3p involving the ACVR1B-SMAD3-PGC-1α signaling axis.
Ruolan Chen, Luning Qin, Ning Zhang, Xuezhe Wang, Zhijun Liu, Xiaojian Xu, Huhu Zhang, Chunjuan Yu, Yice Zhang, Bing Li, Xian-Ming Chu
Abstract
Doxorubicin-induced cardiotoxicity (DIC) limits the clinical use of doxorubicin, yet no specific therapeutic interventions are available. Although the cardioprotective role of miR-210 and the therapeutic potential of stem cell-derived extracellular vesicles have been reported, the specific downstream effectors and pathways mediating the cardioprotective effects of BMSC-EVs against DIC remain poorly understood.
Keywords
<Keyword MajorTopicYN="N">ACVR1BBMSC-EVsDoxorubicin-induced cardiotoxicityMitochondrial dysfunctionmiR-210-3pMicroRNAsAnimalsSignal TransductionDoxorubicinMicePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaCardiotoxicityMice, Inbred C57BLActivin Receptors, Type ISmad3 ProteinMesenchymal Stem CellsMyocytes, CardiacHumans