Epidural cell therapy reduces neurological sequelae severity in canine distemper survivors.
Jaqueline Cardoso do Prado Bayma, Jonathan Edwin Baracho Trindade Hill, Ana Beatriz Molina, Amanda Baracho Trindade Hill
Abstract
Canine distemper has a high mortality rate in the acute phase, and survivors typically suffer irreversible, progressive neurological sequelae, due to demyelinating leukoencephalitis, under current treatment standards. Mesenchymal stromal cells (MSCs) are found in the adult organism and represent a promising alternative for treating central nervous system disorders by secreting trophic and immunomodulatory factors that reduce inflammation, protect neurons, and promote regeneration. The therapeutic action of MSCs is largely mediated by the secretion of trophic and immunomodulatory factors, including anti-inflammatory cytokines, anti-apoptotic proteins, and neurotrophins.