Stem cell research & therapy|March 21, 2026Peer-Reviewed

Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries.

Haochen Tu, Aoi Hosaka, Genki Hichiwa, Yayan Wang, Kanako Kazuki, Toshiaki Tabata, Mitsuhiko Osaki, Yuji Nakayama, Iori Kanazawa, Kazuhisa Honma, Makoto T Kimura, Xu Gao, Norichika Ogata, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki

Abstract

Mesenchymal stromal cells (MSCs) are widely used in regenerative medicine, but their clinical utility is limited by replicative senescence. Strategies that reverse aging while maintaining MSC identity are urgently needed.

Keywords

<Keyword MajorTopicYN="N">Mesenchymal stromal cellsPartial reprogrammingRegenerative medicineRejuvenationSendai virus

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DOI PubMed Source

Rejuvenation of mesenchymal stromal cells via partial reprogramming&#xa0;enables scalable generation of transcriptionally diverse MSC libraries.

Abstract

Keywords

Sources

Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries.