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Stem cell research & therapy|Peer-Reviewed
Macrophage autophagy-dependent M2 polarization mediates the protective effect of ADSC-conditioned medium against acute lung injury.
Jiachen Li, Fan Yang, Ziyi Ren, Chuanyu Zhang, Mingwei Xing, Zhihui Jiao
Abstract
Adipose-derived mesenchymal stem cell conditioned medium (ADSC-CM) has emerged as a promising cell-free therapeutic strategy for acute lung injury (ALI). ADSC-CM's anti-inflammatory effect is closely related to its ability to regulate alveolar macrophage polarization. Furthermore, autophagy in macrophages is considered to be related to the regulation of polarization. However, the specific role and mechanisms by which ADSC-CM coordinates autophagy to guide macrophage polarization are not yet fully clear and urgently require further research.
Keywords
<Keyword MajorTopicYN="N">Acute lung injuryAdipose-derived mesenchymal stem cell conditioned mediumMacrophage autophagyMacrophage polarizationStem cell therapy